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A total of 40 patients were enrolled and a significantly higher reduction in HbA1c was observed in those belonging to Group A, who were given green jackfruit flour, compared to Group B from baseline to week 12.

“The mean change in FPG (The fasting plasma glucose) and PPG (Postprandial Plasma Glucose) was significantly higher in Group A than that of Group B (p = 0.043 and p = 0.001). The continuous glucose monitoring showed decreasing mean blood glucose in 7 days of administration of jackfruit flour meal,” the study said, PTI reported.

“Patients from Group A had a significantly higher reduction in HbA1c, FPG, and PPG than Group B demonstrating the efficacy of jackfruit flour in glycemic control as medical nutrition therapy replacing an equal volume of rice or wheat flour in daily meal.”

This was a randomised, double-blind, placebo-controlled study conducted between May 2019 and February 2020.

Patients of either sex aged 18 to 60 years with a diagnosis of T2DM for one year receiving oral antihyperglycemic agents were randomized (1:1) to receive either jackfruit flour 30 g/day (Group A) or placebo flour (Group B) (breakfast and dinner) daily for 12 weeks replacing an equal volume of rice or wheat flour.

According to Unnikrishnan, the result of the randomised, double-blind, placebo-controlled study, including continuous glucose monitoring highlight the benefits of green jackfruit flour for medical nutrition therapy in diabetes.

“This is a scientific advancement in diabetes from India for India and these results could inspire further research on a traditional Indian diet. I hope that the findings of this research translate into better use of medical nutrition therapy in Type 2 diabetes care in India,” Unnikirshinan, who is Endocrinologist and CEO of Chellaram Diabetes Institute in Pune was quoted as saying.

Gopal Rao pointed to a highlight of the study which was the ease of intervention of green jackfruit flour and placebo in a home setting in India.

“Intervention was culturally sensitive and integrated into traditional home-cooked foods like roti and idli. This helped to achieve a high degree of adherence to the intervention for a full HbA1c cycle of three months,” Rao, Assistant Professor, General Medicine, Govt Medical College, Srikakulam, Andhra Pradesh told PTI.

Joseph, co-author and owner of the startup Jackfruit365, said Medical Nutrition Therapy (MNT) is the first option for Diabetes Care as per ADA guidelines.

This study has proven that it is possible to practice MNT in India for long-duration using Jackfruit365 green Jackfruit flour.